Dr. Neil Nathan protocol for treating mold toxicity and CIRS

Dr. Neil Nathan Protocol


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This medication requires a prescription from your doctor.

  • Amphotericin B 0.06% Solution 1000mL (Reconstitution for Oral Use and Nasal Spray)
  • EDTA 15mg/5mL Nasal Spray
  • Nystatin 50,000 Unit Capsules (Reconstitution for Nasal Atomization)
  • Nystatin 500,000 Unit Capsules (Oral Use)
  • Pure Cholesytramine Resin

The Dr. Neil Nathan protocol for treating illness related to mold exposure involves a combination of established protocols that are customized to the individual patient’s needs. Some patients are sensitive to the typical strengths of medication used for treating mold-related illnesses and this protocol recognizes that. Dr. Nathan recommends a protocol of antifungals, binders, chelators, and supplements for a comprehensive treatment of the multiple aspects of biotoxin illness.

Dr. Neil Nathan Protocol Medications

Amphotericin: Instead of recommending only intranasal antifungals, Dr. Nathan’s protocol calls for the use of oral antifungals as well. Amphotericin is prescribed in a 0.06% strength, which is less than the 0.25% that is often recommended. The amphotericin is supplied in a powder for reconstitution with distilled water. The solution can then be used for intranasal atomization with the RhinoClear Sprint and can also be taken orally.

Nystatin: This antifungal may be prescribed if a patient is sensitive to the effects of amphotericin. It may also be prescribed together with amphotericin for both intranasal and oral use. Nystatin can also be used with the RhinoClear atomizer.

EDTA: The chelating agent EDTA is a part of most mold toxicity protocols for disrupting the biofilm that harbors bacteria. Dr. Nathan calls for the use of an EDTA 15mg/5mL solution for intranasal atomization. The RhinoClear Sprint can be used to administer both the antifungal and the chelating agent. BEG spray, which contains EDTA, is not prescribed as often now as the use of gentamicin for treating mold toxicity has fallen out of favor. In his book, Dr. Nathan recommends the use of the hydrosol silver supplement Argentyn 23 in conjunction with EDTA.

Cholestyramine: Dr. Nathan protocol calls for the use of pure cholestyramine for the right patients. The standard dosing for pure cholestyramine is to take 1 scoop (4g) 3-4 times daily mixed with 8oz of water or juice. Cholestyramine is well-known binder that is a part of most treatment protocols for mold toxicity.

The Dr. Neil Nathan protocol is a combination of recognized treatments for mold toxicity that are finely tuned to the patient’s needs. Instead of a “one size fits all” approach, the protocol allows some flexibility in deciding the types of medication and dosages used. In general the protocol is designed so the patient experiences as few adverse effects as possible while maximizing treatment effectiveness.

RhinoClear Sprint Atomizer

Many of the medications in this protocol can be prescribed to be used with the RhinoClear Sprint atomizer. The atomizer is a portable, battery-powered device that sends a spray of medication into nasal passages. It is available from Woodland Hills Pharmacy as part of your prescription.


Mold and Mycotoxins: Often Overlooked Factors in Chronic Lyme Disease – Scott Forsgren with Neil Nathan, MD, and Wayne Anderson, ND

Intranasal Nystatin Therapy in Patients with Chronic Illness Associated with Mold and Mycotoxins – Global Journal of Medical Research

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