12.5mg/mL, 25mg/mL, 50mg/mL Gel
Promethazine transdermal gel (aka Phenergan Gel) is used to treat nausea and vomiting. The only commercially available forms in the U.S. are tablets and suppositories, although it is available as a cream in other countries. Since oral tablets or suppositories are not always desirable for treating nausea, a transdermal gel may be custom-made by a compounding pharmacy.
Promethazine has a variety of applications and has been used as an antiallergic, a sedative, and to treat motion sickness. For most of these applications, promethazine is taken orally in a tablet. It has been sold in combination with other drugs under many brand names since it was first developed in the 1940s. The most commonly known brand name for promethazine in the United States is likely Phenergan, which is sold in tablets and suppositories.
Promethazine Gel Application
Promethazine transdermal gel should be applied to the wrist every 4-6 hours as needed for nausea and vomiting. It is important that proper precautions be taken to avoid sun exposure when using promethazine as it may make the skin more sensitive. Dermatologists recommend daily use of sunscreen to all of their patients regardless of the medications they are taking.
- Promethazine 25 mg/mL in Pluronic Lecithin Organogel for Nausea and Vomiting in a Pediatric Patient: A Case Report. – International Journal of Pharmacy Compounding