cream bottle used for ketoconazole, miconazole, lactic acid and urea creams

Lactic Acid and Urea Cream

cream bottle used for ketoconazole, miconazole, lactic acid and urea creams

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This medication requires a prescription from your doctor.

Lactic Acid 10% / Urea 40%
Lactic Acid 8% / Urea 40% / Salicylic Acid 1%

Lactic acid and urea together can help soften skin and reduce dryness. These emollient and keratolytic agents are combined into one cream with higher strengths than are commercially available. These formulations are frequently prescribed for treating dermatological conditions of the feet. The ingredients help reduce and prevent itchiness, flaking skin, dryness, roughness, and irritation.

Urea and Lactic Acid

Urea is an emollient that helps increase moisture in the skin and can also act as a keratolytic. Lactic acid is a keratolytic that helps remove dead skin and also improves the skin’s ability to retain moisture. At higher strengths, lactic acid exhibits more exfoliating properties than it does at lower concentrations. It is sometimes included in chemical peels as an exfoliant. Especially on the thick skin on the bottom of the feet, a higher concentration of lactic acid is needed to exfoliate and reduce roughness.

Compounded Formulations

The brand-name product Calmurid, which is no longer available commercially, contained urea 10% and lactic acid 5%. A compounding pharmacy is able to provide a cream with higher concentrations of ingredients – up to urea 40% and lactic acid 10%. Salicylic acid, another keratolytic agent commonly found in OTC skincare products, can also be added to the cream. This high-strength cream with three effective ingredients is only available from a compounding pharmacy.

Applying Urea and Lactic Acid Cream

Lactic acid and urea creams are usually applied in a thick layer to the skin (not rubbed in) and left on for a few minutes. After that the cream is massaged in and any excess wiped off with a tissue. For application to the feet, first wash with warm water and soap, then towel dry before applying the cream. This will help soften the skin and enhance the effects of the cream.


Urea: A Clinically Oriented Overview from Bench to Bedside. – Journal of Drugs in Dermatology (View on PubMed)

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