Drug-Drug Interactions: Do not use sildenafil lozenges when taking other medications containing sildenafil, tadalafil, vardenafil, or with any other ED medications. This includes Viagra, Cialis, and Levitra. Always tell your doctor about any other medications you are taking before starting a new treatment.

Sildenafil rapid-dissolve lozenges have gained much attention as an effective treatment for erectile dysfunction. These lozenges disintegrate and dissolve in the mouth or beneath the tongue within 15-20 minutes. PDE5 inhibitors like sildenafil, tadalafil, and vardenafil are first-line treatments for erectile dysfunction. PDE5 inhibitors work by inhibiting the breakdown of cyclic guanosine monophosphate (cGMP) in the smooth muscle of the penis. PDE5 inhibitors in the form of lozenges are not commercially available and can only be made by a compounding pharmacy.

Sildenafil Lozenges – Rapid Onset

Fast-acting sildenafil lozenges promote quick absorption and rapid onset. Sildenafil lozenges kick in faster than their tablet counterpart, in as little as 15 minutes. Since the lozenges are dissolved under the tongue they start working much faster than a tablet that has to pass through the digestive system. A sublingual dosage form is not as effected by food ingestion as the orally administered tablets.

Studies have shown that sublingual sildenafil is safe and effective.  In one study, sixty‐five percent of patients (13/20) who received sublingual sildenafil achieved satisfying erections and coitus, whereas the rate was 15% in the placebo group (3/20). Minimal side effects were noticed and included headache, sweating, and flushing.

Research

Sublingual sildenafil in the treatment of erectile dysfunction: Faster onset of action with less dose – International Journal of Urology

The start of pharmacological activity after sublingual administration of sildenafil citrate in 30 patients affected by erectile dysfunction. – Archivio Italiano di Urologia e Andrologia