Mitochondrial Cocktail


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This medication requires a prescription from your doctor.

Mixture of vitamins, supplements, and co-factors

A mitochondrial cocktail is a mixture of ingredients used for treating mitochondrial disease or dysfunction. There are a variety of supplements, co-factors, and vitamins that may be recommended as part of a treatment regimen for conditions related to mitochondrial dysfunction. Taking each of them individually can be difficult. For pediatric patients in particular, it may be impossible to comply with a routine that includes a dozen pills or more. A compounding pharmacy can prepare a combination of essential vitamins for mitochondrial disease in one formulation. This combination is sometimes called a mitochondrial “cocktail” because it is a mixture of ingredients in a drinkable form.

Why Use a Mitochondrial Cocktail?

There are many different types of mitochondrial disease and a vitamin that works for one patient may not work for another patient. Since disease-causing mutations in mitochondrial DNA were discovered in 1988, there have been at least 275 other harmful mutations found. A healthcare provider prescribes a mitochondrial cocktail when their patient is not getting certain vitamins their body needs to manage the condition. Most individuals can get all of the vitamins they need through a healthy diet, however patients with deficiencies in their diet or certain health conditions often benefit from supplementation. Since there are a dozen or more vitamins and supplements that may help those with mitochondrial disease, putting the ingredients all together into one formulation can be beneficial.

Mitochondrial Cocktail Ingredients

The following vitamins and supplements are commonly included in mitochondrial cocktails prescribed for mitochondrial dysfunction and disease. A formulation can contain only a few of these ingredients or all of them.

  • L-Carnitine (Acetylcarnitine)
  • Coenzyme Q10 (C-Q10)
  • Riboflavin (B2)
  • Creatine Monohydrate
  • Vitamin C
  • Vitamin E
  • Alpha Lipoic Acid
  • Thiamine (B1)
  • Niacin (B3)
  • Biotin
  • Folic Acid

Compounding for Mitochondrial Disease

A mitochondrial cocktail can be customized by our compounding pharmacy to include only those ingredients recommended by your healthcare provider. You can discuss compounded treatment options from our pharmacy with them or have them call us directly to discuss your options.

For prescribers: Click here to view a calculator for determining TID dosage of mitochondrial cocktail by weight.


A Modern Approach to the Treatment of Mitochondrial Disease – Current Treatment Options in Neurology (PubMed) 

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