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This medication requires a prescription from your doctor.

Isometheptene 65mg, Caffeine 20mg, Acetaminophen 325mg in Capsules

Prodrin is a combination migraine medication that contains some of the same ingredients as the popular migraine medication Midrin. It contains acetaminophen and isometheptene but instead of dichloralphenazone, which is a mild sedative, it contains caffeine. Like isometheptene, caffeine is a vasoconstrictor that helps reduce the vasodilation associated with migraines and severe headaches. Caffeine also acts as a central nervous system stimulant, which may help alleviate some of the pain of severe headaches. Migraines are a common condition globally and in the United States affect about 1 in 10 people. They are more common in women and in those with medical conditions like depression, anxiety, and bipolar disorder. Medications like Prodrin have helped many people reduce the severity of their migraines and severe headaches.

Prodrin Ingredients

Prodrin is taken for acute treatment of migraines. That means that it should be used as-needed at the onset of an attack or as soon as possible after the onset. It is not intended for use on a daily basis as a preventative treatment. The ingredients in Prodrin are meant to ease the pain of migraines and severe headaches as they are occurring. Isometheptene and caffeine are vasoconstrictors that help with headaches that are associated with widening of the blood vessels in the head (vasodilation). Acetaminophen is a pain reliever that can help with many different types of headaches and pain throughout the body.

How to Prescribe

Prodrin requires a prescription and can be obtained from a compounding pharmacy. The prescription should include each of the ingredients and their strengths along with the dosing. The most common strengths are isometheptene 65mg, caffeine 20mg, and acetaminophen 325mg. At the onset of a migraine, 1-2 capsules should be taken. This can be followed with 1 capsule every hour, with a max dosage of 5 capsules in a 12 hour period. While acute treatments like Prodrin can be helpful, it is essential to maintain a healthy lifestyle and minimize triggers to reduce the frequency and severity of migraines.

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