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This medication requires a prescription from your doctor.
Clotrimazole 3%, Miconazole 3% in DMSO Solution
Onychomycosis (toenail fungus) can be difficult to treat with over-the-counter medications. Compounded treatments can contain multiple antifungals in combination with other effective ingredients. The ability for a medication to penetrate the nail plates is always an important consideration when treating fungal infections of the nails. Antifungals on their own are not enough to get through the nail. DMSO (dimethyl sulfoxide) is a by-product of paper making that comes from substance in wood. DMSO combined with antifungals enhances their ability to penetrate to the infection.
Topical Application of Antifungals
While orally administered antifungals can be effective, they also increase the chance of toxicity – especially if combined with other medications. Oral antifungals need to be taken for long periods of time, which can cause liver damage in some individuals. A topical antifungal treatment can treat the infection directly without adverse effects on other parts of the body. The only problem with application of a topical antifungal is that it is difficult for it to penetrate the nail to the infection. Including DMSO in the formulation improves the ability of the antifungals to get through the nail. DMSO is non-toxic and penetrates through the nail bed – pushing the antifungal ingredients towards the infection.
Directions for Use of Antifungal DMSO Solution
Clotrimazole and miconazole are two azole antifungals proven to treat toenail fungus. They are combined with DMSO in solution form that is usually prescribed to be used once or twice daily. The solution should be applied after bathing and drying to maximize penetration to the infection. Application should continue daily until the nail grows out clear.