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minocycline gel kit

Dental Antibiotic – Alternative to Arestin

minocycline gel kit

Dental Antibiotic – Alternative to Arestin

The commercially available drug minocycline hydrochloride is sold under the brand name Arestin in microsphere form. While many dentists who treat periodontal disease have found this product to be effective, the cost per application site can make it an expensive treatment. The expense that must be passed on to the patient is especially high if multiple sites need to be treated. Having a topical antibiotic for treating periodontal disease does not need to be expensive though. Minocycline is a tetracycline antibiotic that has been used for many years and is available in formulations from a compounding pharmacy. Dentists have found our 2% minocycline gel to have the same effectiveness as Arestin and some have found it to be more effective.

Antibiotic Treatment for Periodontal Disease

Antibiotics have been shown to be effective as adjunct treatments for multiple types of periodontal disease. In some cases they are prescribed in oral form but more commonly are made into topical gels. A topical gel is usually preferred as it reduces the risks of systemic effects from oral antibiotics and treatment is targeted to the area of infection.

A topical antibiotic gel can control the re-colonization of bacteria after instrumentation. This is the FDA indication for the commercially available product Arestin. Arestin is a form of the antibiotic minocycline that reduces pocket depth when combined with scaling and root planing. Minocycline is a tetracycline antibiotic that has both anti-bacterial and anti-inflammatory properties. It also helps prevent tissue destruction and bone loss by blocking the protein collagenase.

Minocycline 2% Gel

Arestin is dental antibiotic in microsphere form that is administered directly to the periodontal pocket. A minocycline 2% gel compounded by a pharmacy can be used as an alternative. The gel is placed into the periodontal pocket after scaling and root planing to kill bacteria that are causing gum disease. Dentists we work with have found the gel to be just as effective as Arestin and more affordable.

Minocycline 2% gel must be mixed by the dentist to ensure stability of the medication. Our kits come with two Luer lock syringes: one with the minocycline powder and one with the gel. The two must be mixed together in the office then drawn into 1.2cc syringes for application. After mixing, the gel has an expiration date of 5 days. If the medication is not activated it has a 6-month expiration date. Whether the medication is activated or not it should always be kept refrigerated.

An Adjunct to Scaling and Root Planing

Studies have demonstrated the effectiveness of combining minocycline gel with regular periodontal treatment. Follow-up visits for periodontal treatment will result in less bleeding on probing and less inflammation when minocycline 2% gel is used as an adjunct treatment. Although has not been extensive research done on minocycline gel as a monotherapy, it has been shown to work well when combined with regular scaling and root planing. Instrumentation alone is not likely to remove all pathogens in infected pockets, which makes minocycline 2% gel an effective way to manage periodontal disease between office visits.

Minocycline Gel vs. Arestin Price

If your office has been looking to buy Arestin you may be surprised at the high cost per treatment. The cost of Arestin is significantly higher than the cost of obtaining minocycline 2% gel from a pharmacy. Especially when using the product on multiple treatment sites, it may be a huge cost savings to use compounded minocycline gel.

Minocycline Gel vs. Arestin Effectiveness

It’s clear that minocycline 2% gel from our compounding pharmacy is much more affordable than Arestin. In addition to price, some dentists we work with have told us that the gel is actually more effective. With the low cost of our product, many dentists find that it is worth it to try and compare the gel with the commercially available Arestin powder.

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8 thoughts on “Dental Antibiotic – Alternative to Arestin

    1. woodlandhills pharmacy Post author

      Please call our office for information about prescriptions and ordering. We can be reached at 855-876-3060.

      Reply
  1. Paul Hutchinson

    One of the benefits of Arestin is that you can use it as you go when you need it as long as it doesn’t expire. Isn’t it true with this substitute you have to mix the whole thing and use it within a few days? We don’t typically use it that often. Do you have something similar that offers the flexibility of using it when we need it? I’ve got to find something other than Arestin…it’s way overpriced IMHO.

    Reply
    1. woodlandhills pharmacy Post author

      After mixing it should be used within 5 days. However unmixed its expiration is 6 months. Even with the 5-day expiration, dentists tell us that they find the alternative compounded product to be more cost-effective.

      Reply
      1. Chau

        The website state once mixed it is only good for 5 days. This reply states is can last up to 10 days. Which is the correct amount of days I have to use the antibiotic once mixed.

        Reply
  2. stacey

    I understand that once mixed it has to be used within 5 days. Can you mix a very small dosage or do you have to mix the entire syringe(s) at one time? That may be what Paul was asking, I just wanted to clarify if I misunderstood.

    Reply
    1. woodlandhills pharmacy Post author

      Because the syringes are mixed by connecting them together, and the ratio of ingredients is measured to match one syringe to one syringe, the entire syringe must be mixed at one time.

      Reply

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